Solvent to Aqueous Switches

Generally, there are a few main reasons why processes today utilize organic solvents. The obvious first reason is that the product was developed many years ago and have never been updated. Second, is potential degradation of the API due to hydrolysis. Third may be due to the use of controlled release polymers that are water insoluble to modify the drug release of the API. Some products may be very difficult to manufacture in an aqueous environment such as hydrophilic matrix or osmotic pump formulations. Lastly, many new poorly soluble drugs may utilize organic solvents in order to create amorphous solid dispersions.

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